ABSTRACT
Background and aim: Enhancement of blood factor 7 or fibrinogen is considered as cardiovascular risk factors. This study was, therefore, aimed to evaluate the effects of Sesamum indicum seed and oil on fibrinogen and factor 7 in hypercholesterolemic rabbits
Methods: In an experimental study, 32 New Zealand rabbits were randomly designated into 4 groups of 8 and were fed for 60 days as following: normal diet, hypercholestrol [1%] diet, hypercholestrol [1%] diet+10% sesame seed, hypercholestrol [1%] diet+5% sesame oil. At the beginning and 60 days after the start of the study, the blood fibrinogen and factor 7 were measured and compared in different groups
Results: There was no difference for fibrinogen and factor 7 in different groups at the start of the study, however, the blood fibrinogen and factor 7 were increased in hypercholesterolemic group compared to normal diet group [P<0.05]. The amounts of blood fibrinogen and factor 7 were decreased in hypercholesterol+sesame seed and in hypercholesterol+sesame oil groups compared to hypercholesterol diet group [P<0.05]
Conclusion: Sesame seed and oil may have beneficial effects on cardiac function by decreasing blood fibrinogen and factor 7 as cardiovascular risk factors
ABSTRACT
The influence of morphine on pituitary secretion through micrimu receptors has been nearly known. It is also reported that morphine has an effect on cell proliferation. In the present study we investigated the effect of morphine on the proliferation of acidophil cells of adenohypophysis in male rat. This study has been carried out on 14 adult male Wistar rats divided into two groups of morphine dependent and control. The animals in morphine-dependent group were addicted through consumption of morphine for 21 days. After controlling withdrawal syndrome signs, serum prolactin level was determined by Elisa method. In the next step after anesthetizing animals and performing cardiac perfusion, the hypophysis was removed and fixed at 10% formalin. After processing, staining was done by routine immuno-histochemistry method and the number of mammotropes and somatotropes in morphine-dependent and control groups were compared. Mean prolactin production in dependent group as compared with control group showed significant increase. There was a significant increase in the ratio of mammotropes to acidophil cells and a significant decrease in the ratio of somototrops to acidophil cells in morphine-dependent group compared to the control group [P<0.05]. Morphine dependency may lead to increase in the percentage of prolactin secreting cells and serum prolactin level and decrease of growth hormone secreting cells